This study examines the prevalence of breast, cervical, and colorectal cancer screening across the US-Affiliated Pacific Islands (USAPI), including American Samoa, CNMI, Palau, RMI, and the FSM states of Pohnpei and Kosrae. Using data from population-based cross-sectional surveys conducted between 2016 and 2019, researchers assessed screening rates and disparities by sociodemographic and health characteristics. Findings revealed suboptimal screening rates: 20.6% for breast, 38.6% for cervical, and 15.1% for colorectal cancer. Lower screening prevalence was associated with lower education levels, diabetes, and tobacco use. The study underscores the need for culturally tailored and resource-appropriate strategies to enhance cancer screening uptake and reduce health disparities in the region.